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| SCIENCES DE LA SANTE [ S.S. ] |
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BioAfrica |
| Auteurs de l'article |
| TARIAM DJIBANGAR AGNÈS, ROMUALD DASSÉ SÉRY, KOUABLA LILIANE SIRANSY, RICHARD YÉBOAH OPPONG, ADJOUMANVOULÉ HONORÉ ADOU, SANSAN HIEN,AMAH PATRICIA VICTORINE GORAN-KOUACOU, KOFFI N’GUESSAN, BABAC |
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Num ISSN : 10-3427-09 [ Semestriel ] |
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Parution N° 17 du 28-02-2019 |
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Volume : - de l'année 2018 |
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| LE PROFIL DES CYTOKINES TH2 ET LA SUSCEPTIBILITÉ AU PALUDISME GRAVE EN ZONE ENDÉMIQUE
pp. 49-53. |
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| Introduction: Malaria, a disease caused by protozoan parasites of the genus Plasmodium. Despite the premunition, some adults still experience the severe form of malaria. The study hereby aims to investigate the involvement of Th2 cytokines profile in the resistance to severe malaria in endemic areas. Patients and methods: It was a prospective study with an analytical focus on a 3-year period from July 30, 2015 to February 23, 2018. The study covered 150 patients, 50 patients suffering from simple malaria, 50 others hospitalized for the severe form and 50 witnesses. All the analyzes were conducted within the Laboratory of the University Hospital of Cocody.
Results: It is clear that, the average level of antibody according to the clinical status is meaningless, and Th2 cytokine levels (IL-4, IL-10) are higher in simple malaria compared to severe malaria and witnesses. Moreover, there is no correlation between the average level of Th2 cytokines and the average level of antibodies. Conclusion: Severe adult malaria in endemic areas is associated with humoral immunity and this is not dependent of the premunition and acquisition of IgG antibodies |
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